Looking for something specific not listed here? Visit mushroom references for a comprehensive compilation of scientific papers on medicinal mushrooms and their proven benefits 

Link: www.mushroomreferences.com

Lion's mane (Hericium erinaceus)

Title: Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus

Link: https://www.tandfonline.com/doi/full/10.1080/21501201003735556

Insert: " It is interesting that hericenones have been only reported in the fruiting bodies of H. erinaceus and erinacines only in the mycelia."


Title: Enhanced Erinacine A Production by Hericium erinaceus Using Solid-State Cultivation" 

Link: http://mushroomreferences.com/2022/05/20/enhanced-erinacine-a-production-by-hericium-erinaceus-using-solid-state-cultivation/

Insert: "Erinacine A (ErA) is a secondary metabolite presented in the mycelia of HE, with pharmacological effects as a nerve growth factor on the central nervous system."

Title: Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus 

Link: https://pubmed.ncbi.nlm.nih.gov/22982810/

Insert: "The HEP80 showed strong activity on antioxidant and hepatoprotective activities. ► The hepatoprotective effect may be due to its potent antioxidant capacity."

Title: "Preclinical Bioavailability, Tissue Distribution, and Protein Binding Studies of Erinacine A, a Bioactive Compound from Hericium erinaceus Mycelia Using Validated LC-MS/MS Method"

Link: http://mushroomreferences.com/2021/10/22/preclinical-bioavailability-tissue-distribution-and-protein-binding-studies-of-erinacine-a-a-bioactive-compound-from-hericium-erinaceus-mycelia-using-validated-lc-ms-ms-method/

Insert: "This study is the first to show that erinacine A can penetrate the blood-brain barrier of rats by the means of passive diffusion and thus support the development of H. erinaceus mycelia for the improvement of neurohealth."


Title: Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds"

Link: http://mushroomreferences.com/2019/03/19/chemistry-nutrition-and-health-promoting-properties-of-hericium-erinaceus-lions-mane-mushroom-fruiting-bodies-and-mycelia-and-their-bioactive-compounds-2/

Insert: "The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds include antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipodemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression."


Title: "Erinacine A-enriched Hericium erinaceus mycelia promotes longevity in Drosophila melanogaster and aged mice"

Link: http://mushroomreferences.com/2019/10/18/erinacine-a-enriched-hericium-erinaceus-mycelia-promotes-longevity-in-drosophila-melanogaster-and-aged-mice/

Insert: " Results showed that supplementation with erinacine A-enriched H. erinaceus mycelia extended the lifespan in both D. melanogaster and SAMP8 by a maximum of 32% and 23%, respectively, compared to the untreated controls. Moreover,...."


Reishi (Ganoderma lucidum cplx)

Title: Ganoderma Lucidum(Reishi) in Cancer Treatment

Link: https://journals.sagepub.com/doi/abs/10.1177/1534735403259066

Insert: "Thus, Ganoderma lucidum clearly demonstrates anticancer activity in experiments with cancer cells and has possible therapeutic potential as a dietary supplement for an alternative therapy for breast and prostate cancer."


Title: Reishi, Ganoderma lucidum and Ganoderma tsugae: Bioactive substances and medicinal effects

Link: https://www.tandfonline.com/doi/abs/10.1080/87559129509541025?journalCode=lfri20

Insert: "Unlike chemicals used in chemotherapy, it has few side effects because it's effect is based on immunological enhancement in the host"


Title: Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides

Link: https://www.sciencedirect.com/science/article/abs/pii/S0968089604006054

Insert: "Together with previous studies, the mode of action on macrophages has been proposed where F3 binds to TLR4 receptor and activates extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 to induce IL-1 expression."


Title: Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of Ganoderma lucidum (reishi mushroom)

Link: https://www.sciencedirect.com/science/article/abs/pii/S0367326X11003285

Insert: "The active compounds were determines as nonadecanoic acid and cis-9-nonadecenoic acid."


Title: "Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells."

Link: http://mushroomreferences.com/2020/10/02/ganoderic-acid-t-from-ganoderma-lucidum-mycelia-induces-mitochondria-mediated-apoptosis-in-lung-cancer-cells-2/

Insert: "All our findings demonstrate that GA-T induced apoptosis of metastatic lung tumor cells through intrinsic pathway related to mitochondrial dysfunction and p53 expression, and it may be a potentially useful chemotherapeutic agent."


Title: "Medium composition optimization, structural characterization, and antioxidant activity of exopolysaccharides from the medicinal mushroom Ganoderma lingzhi"

Link: http://mushroomreferences.com/2019/03/19/medium-composition-optimization-structural-characterization-and-antioxidant-activity-of-exopolysaccharides-from-the-medicinal-mushroom-ganoderma-lingzhi/

Insert: "These findings indicated that RSM is an efficient tool to predict the composition of culture medium required for maximizing GLEPS yield, and GLEPS had potent antioxidant activities and could be explored as a novel natural antioxidant in functional food or medicine."


Title: "Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response"

Link: http://mushroomreferences.com/2017/09/21/polysaccharides-from-ganoderma-lucidum-attenuate-microglia-mediated-neuroinflammation-and-modulate-microglial-phagocytosis-and-behavioural-response/

Insert: "Overall, our study provides an insight into the GLP regulation of LPS- and Abeta-induced neuroinflammation and serves an implication that the neuroprotective function of GLP might be achieved through modulation of microglial inflammatory and behavioural responses."


Cordyceps (Ophiocordyceps militaris)

Title: Beneficial Effect of Cordyceps militaris on Exercise Performance via Promoting Cellular Energy Production

Link: https://www.tandfonline.com/doi/full/10.1080/12298093.2020.1831135

Insert: "Therefore, C. militaris has the possibility of improving exercise performance, which could be associated with the increase in ATP production rather than the decrease in muscle fatigue during exercise."


Title: Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909570/

Insert: "Main constituent of the extract derived from this fungus comprises a novel bio-metabolite called as Cordycepin (3′deoxyadenosine) which has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities."


Title: Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms

Link: https://www.mdpi.com/2076-2607/10/2/405/htm

Insert: "These functions make C. militaris a suitable functional food for inhibiting inflammatory responses such as the regulation of proinflammatory cytokines. Therefore, on the basis of existing information, the current study provides insights towards the understanding of anti-inflammatory activity-related mechanisms."


Title: Neuroprotective effects of cordycepin inhibit Abeta-induced apoptosis in hippocampal neurons

Link: https://mushroomreferences.com/2018/10/09/neuroprotective-effects-of-cordycepin-inhibit-abeta-induced-apoptosis-in-hippocampal-neurons-2/

Insert: "Results showed that the anti-apoptotic effects of cordycepin are partially dependent on the activation of adenosine A1 receptor, whereas an antagonist selectively attenuated the neuroprotective effects of cordycepin. Collectively, these results suggest that cordycepin could be a potential future therapeutic agent for neuronal disorders, such as AD."


Chaga (Innonotus obliquus)

Title: Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus

Link: https://www.sciencedirect.com/science/article/abs/pii/S0031942220312620

Insert: "These results indicated that the potential anti-inflammatory effects of inonotusols I and L in microglial BV-2 cells may be imparted through suppression of iNOS. These results may support the use of I. obliquus for food and medicinal application."


Title: Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer

Link: https://www.sciencedirect.com/science/article/abs/pii/S0378874115300477

Insert: "These properties of ergosterol peroxide advocate its use as a supplement in colon cancer chemoprevention."


Title: Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice

Link: https://www.sciencedirect.com/science/article/pii/S2405844016301773

Insert: "Our findings suggest that the I. obliquus extract could be used as a natural remedy for cancer suppression by promoting energy metabolisation"


Title:  Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

Link: https://synapse.koreamed.org/articles/1051060

Insert: "All of the subfractions isolated from I. obliquus showed significant cytotoxic activity against the selected cancer cell lines in vitro."


Title: Effect of steam treatment on soluble phenolic content and antioxidant activity of the Chaga mushroom (Inonotus obliquus)

Link: https://www.sciencedirect.com/science/article/abs/pii/S0308814609008772

Insert: "Consequently, the radical scavenging activity was also significantly enhanced by free phenolics produced using this method."


Title: New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus

Link: https://www.sciencedirect.com/science/article/abs/pii/S0960894X0701253X

Insert: "These compounds exhibited significant scavenging activity against the ABTS radical cation and DPPH radical, and showed moderate activity against the superoxide radical anion."


Title: Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract

Link: https://www.sciencedirect.com/science/article/abs/pii/S1383571808003008

Insert: "Thus, we show that the 3β-hydroxy-lanosta-8, 24-dien-21-al and inotodiol components of Inonotus obliquus bear antimutagenic and antioxidative activities."


Turkey tail (Trametes versicolor)

Title: Trametes versicolor Mushroom Immune Therapy in Breast Cancer

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845472/

Insert: "Immune therapy utilizing the polysaccharide constituents of Trametes versicolor (Tv) as concurrent adjuvant cancer therapy may be warranted as part of a comprehensive cancer treatment and secondary prevention strategy."


Title: Trametes versicolor: A possible tool for aflatoxin control

Link: https://www.sciencedirect.com/science/article/abs/pii/S0168160505005234

Insert: "Filtrates and fractions from T. versicolor could be promising agents in the challenge against aflatoxins."


Title: Medicinal Value of Turkey Tail Fungus Trametes versicolor (L.:Fr.) Pilát (Aphyllophoromycetideae). A Literature Review

Link: https://www.dl.begellhouse.com/journals/708ae68d64b17c52,1b1b20957ef5c8f4,210d57c00e88b78c.html

Insert: "New clinical trials demonstrate improved quality of life after surgery and in combination with chemotherapy, as well as extended 5- and 10-year survival rates, especially for patients with colorectal and stomach cancers."


Title: The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro

Link: https://link.springer.com/article/10.1186/s12906-019-2681-7

Insert: "The results demonstrated that the immune-activating bioactivity of a mycelial-based medicinal mushroom preparation is a combination of the mycelium itself..."


Title: Assessment of Bioactive Compounds and Antioxidant Activity of Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes)

Link: https://www.dl.begellhouse.com/journals/708ae68d64b17c52,3d8e7b4f6342518e,4675f12b644a5c81.html

Insert: "... support the potential use of T. versicolor as a promising source of bioactive products for pharmaceutical and also food industries."


Title: Hepatoma Cell Growth Inhibition by Inducing Apoptosis with Polysaccharide Isolated from Turkey Tail Medicinal Mushroom, Trametes versicolor (L.: Fr.) Lloyd (Aphyllophoromycetideae)

Link: https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2da9c44d295f30f8,7f28c3fe35084a57.html

Insert: "These results thus indicate that CVPs can be a potential candidate to ameliorate toxic effects when used in cancer therapy."


Tramella (Tramella fuciformis) 

Title: Free-radical degradation by Fe2+/Vc/H2O2 and antioxidant activity of polysaccharide from Tremella fuciformis

Link: https://www.sciencedirect.com/science/article/abs/pii/S0144861714006067

Insert: "It was possible that free-radical degradation is an effective way for enhancing antioxidant activity to decrease molecular weight of polysaccharides."

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